His skin became itchy and his eyes were too. I wanted to investigate a bit before dosing him. He just couldn't stand good, he constantly shakes his head. 5 hours after the dose she's home resting. The next month on a sunny weekend, we have him his meds and took him on a walk with his basket muzzle. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I dont know what to do to get this out of their system?? My 8 month old labradoodle has had 2 doses of Simparico Trio. (toy aussie & corgi). My Jack Russell Terrier has taken Simparica Trio for several months. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. Other less common side effects may include tremors, muscle tremors, and seizures. My husband said , get dressed were taking him in . I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets), is the first once-monthly, chewable tablet that delivers all-in-one protection from heartworm disease, ticks and fleas, roundworms and hookworms. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. He had gone to a new groomer and when he came home he had a seizure. They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. I have every intention of calling and filing a complaint. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. He seems dehydrated. Did your dog pass away? Im so angry at these drug companies and vets for selling this crap. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! Exactly. So I started searching and came across this blog and my heart just sank. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. All oral tick meds are a risk. We hope this will solve our problems and he can live a healthy and happy life. Buddy 8 year old male Boxer formerly energetic and playful. Did you ever do an MRI or spinal tap? He is still not himself, walks very slowly and is definitely not feeling his best. Even when asked to go for a car ride he didn't respond. I will never give another dose to him! I also lost my dog due to simparia Trio. Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. There was no clear diagnosis but it was clearly neurological. Over the past month she has stumbled a few times when on walks. In more rare cases, excessive drooling, lethargy, tremors, and convulsions have been reported at very high doses. Our guy is having pain and is showing arthritic symptoms. You seem like an idiot. I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. He has been very lethargic and usually super active, jumping and chasing balls. Our vet pushed this new drug for this tick season claiming the drug we used previously they had 11 dogs in the previous year were diagnosed with Lyme disease and they no longer had confidence in that drug. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. And urinating more often as a result. Thank you to all of you posting and I hope all of your babies are doing well. Then he came too . He was lethargic & laying in his crate alot . I am so angry. All the swelling went down immediately and the itching went away too. He eats and drinks fine but looks like we havent fed him in days. How long did these symptoms last? How do I get this out of his system and what are you using instead? He was on comfortis oral for years with no issues. Daily Paws is part of the Meredith National Digital Network. Both my dogs have had runny eyes and were eating grass all summer. Vet trip and meds $400! Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Mine has tremors once in a while and now I know why! They don't really have an answer for why this happens at all, or why some dogs get better and some don't. You keep your dog cages? However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. She seems more anxious now and really attached to hubby. Seems like it was directly related to the medication. Was not too excited about it, and I really should've declined it. Supply ran out, switched to Simperica. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. I would not recommend giving Simparica to your pets!!!!! And has been for about 3 weeks. I just gave Bentlee my Akita Simparica Trio on the 9th. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. Does this sound familiar to anyone? Topical only for me from now on. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Thank you all so much!!!! She does have history of seizures. While she has not had seizures, trembling, or spasms, sometimes she just squeals and jumps up for no obvious reason. I took him to the ER they checked his vitals and sent me home. Is it too late? Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. Luckily, Simparica Trio for dogs is considered fairly safe. Seizures are going on two hours.. Im trying to understand how. She had terrible watery diarrhea and is not interested in eating. I gave my black lab mix Simparica for the 1st time on 4/1. Then she started having tremors. It is better but not gone. In very rare instances, mild side effects and irritations can occur for a short period of time. Pet Bucket Ltd is a UK registered company|Company no: 08345021|BTC Bessemer Drive Stevenage, SG1 2DX UK. It may be that he is getting older as he is now one years old and he was neutered about three months ago. I gave my 15 year old dog this medicine. This was the first time she was given this drug and will be the last. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". The results are fatal for fleas and ticks but safe for mammals such as your dog. They want another blood draw in 3 weeks to see where she is. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. Yesterday one baby threw up four times within one hour of taking her chewable. I just almost had a similar incident with my 16wk cavapoo. Pharmaceuticals are killing people and pets. He was diagnosed with "Sundowners" . Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. Initially I noticed minor tremors and twitching when he slept or was just relaxing. For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). Does any one think this could be a reaction to Simparico Trio? How can it not be the Simparica that did this to my baby when nothing else changed. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). It went away, I thought the diarrhea was from some of the junk she eats off of the ground. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. Now her dog is very sick and she has to take the dog to the vet every day in the past week. But I have heard of other dogs who recover, or who continue having seizures but not fatal. Next day she seemed different, standing slightly strangely. Puppy Simparico Trio for the first time 2 days ago. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . I never missed a day. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Would appreciate any opinion you all may have. She is healing and has no new rashes or sores. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. Never again are my dogs getting oral medication for fleas & ticks. If she had just taken it they could give her Charcoal. this is how Simparica works on insects who bite your dog. Do you have a homeopathic vet in your area? Same here! Thank all who have posted to bring this subject to light. Neurologist doesnt seem to really know if the effects are long term or not. Anyway, he prescribed him pain relief for 7 days. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! Those jaw spasms have decreased but were pretty alarming in Dec and January. I'm so sorry. Took him back to the vet. Im so upset with myself. I am so sad to read what is happening to some pets. - she's had several episodes since then. I PRAY that our baby is okay with this second dose. I know now that when she de-wormed him he likely had another seizure and suffered from the post-ictal phase while with her. What should I do? He already has canine dementia on and off. All went well until this morning. He had an MRI and it came out good. I'm also wondering if his anxiety is related as well. have been seen after using medications in this class of drugs. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I thought right away it must be the new meds! I threw him his ball and he actually was interested in it. My 3 other poodles unaffected. Then they come back! Simparica Trio: A One-Stop-Solution For Parasites. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. He is 5 months old. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. I'll continue to watch her. 13 March he is also very lethargic and sitll not eating (even his favorite treats). So no Addisions. These dog training tips will help you get started. Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Instead it has become a world of greed. He is otherwise normal and healthy. 2-6 days in vomiting here and there. Youre an idiot then! Sorry to hear about this happening to so many. Side effects of Simparica Let us now look at possible side effects when administering Simparica. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. Some dogs also experience a temporary loss of appetite and may not eat their food at their usual meal times. I guarantee he will not take this trash again. I definitely will not poison her with this garbage anymore. Argh. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. My personal dog has had no issues at all, and she's been on it for nearly two years. She falls when she runs and when going up and down stairs. She text me asking if she ever had seizures before. She is still eating but she is drinking more water. corgi lying in grass next to woman's feet. Simparica uses Sarolaner, which works by overstimulating the nervous system of the pests. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. Or has it been too many doses ? Im not sure if the simperica is the cause. 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